Potential Use of Musa Sapientum Peel Gum as Adhesive in Paracetamol Tablets

  • Uduma E Osonwa University of Houston College of Pharmacy
  • Stephen Olaribigbe Majekodunmi University of Uyo
  • Chukwunonso Chukwudike Onwuzuligbo Nnamdi Azikiwe University
Keywords: Excipient Development, Musa Sapientum

Abstract

This work is an attempt at converting waste products from food, peels of Musa sapientum into useful pharmaceutical excipient. The gum from the peels was extracted, dried and pulverized by an already established method.  A similar process was carried out with M. acuminata peels.  Interaction studies were carried out using differential scanning calorimetry (DSC).  Paracetamol granules were prepared with mucilage of the gums extracted from the peels at concentrations of 2, 4, 6, 8, and 10%w/w of tablet weight using the mucilage and employing the wet granulation approach.  Similar batches of paracetamol granules were prepared using sodium carboxymethyl cellulose (SCMC).  The flow and compressibility properties of the granules were evaluated.  The granules were compressed into tablets and evaluated for hardness, friability, disintegration and dissolution.  The DSC results reveal that the gum is compatible with paracetamol.  Also the gum compared favorably with that of M. acuminata and also SCMC in terms of compact characteristics, such as hardness [M. sapientum- 2% (6.55±0.86); 4% (6.00±0.53); 6% (5.60±0.39); 8% (5.50±0.67); 10% (5.35±0.46): M. acuminata- 2% (4.60±0.74); 4% (5.65±0.53); 6% (5.50±0.33); 8% (6.00±0.41); 10% (6.45±1.07): SCMC – 2% (6.55±0.28); 4% (9.23±1.20); 6% (11.65±2.74); 8% (13.39±2.13); 10% (6.20±2.45)], disintegration [M. sapientum – 2% (11±1.7sec); 4% (10±0.9 sec); 6% (15±1.4 sec); 8% (12±1.4 sec); 10 (11±1.4 sec): M. acuminata – 2% (19±1.4 sec); 4% (17±1.3 sec); 6% (12±1.0 sec); 8% (13±0.9 sec); 10% (18±0.9 sec): SCMC – 2%, 4%, 6%, 8% and 10% > 15mins].  Drug release from the tablets formulated with the M. sapientum gum was rapid, reaching 100% within 30 minutes.  This is similar to the release profile of tablets formulated with M. acuminata, whereas tablets formulated with SCMC had much longer release times.  Friability values were higher with M. sapientum gum2% (14.56%); 4% (23.73%); 6% (15.03%); 8% (14.18%); 10% (14.57%): M. acuminata – 2% (11.76%); 4% (8.08%); 6% (10.58%); 8% (3.29%); 10% (0.18%): SCMC – 2% (1.61%); 4% (0.21%); 6% (0.11%); 8% (0.09%); 10% (0.28%), thus admixtures with SCMC might be a good option.  The gum from M. sapientum gave a yield of 65% (w/w) which was high and the starting material is readily available.  Thus, it could be an alternative source of adhesives suitable to be employed for the manufacture of immediate release paracetamol tablets.

Author Biographies

Uduma E Osonwa, University of Houston College of Pharmacy
Postdoc, Department of Pharmacological and Pharmaceutical Sciences
Stephen Olaribigbe Majekodunmi, University of Uyo
Department of Pharmaceutics and Pharmaceutical Technology
Published
2017-08-13